Perceived as a “six-pointer”, Burnley managed to beat Everton 3-2 on Wednesday, putting pressure on Frank Lampard with an unfavourable fixture list featuring Chelsea and Liverpool.
Meanwhile, Arsenal will aim to return to the winning column this week and boost their Champions League qualification prospects after their 3-0 loss to Crystal Palace on Monday.
Here is i’s gameweek 32 injury update:
Ruben Dias will not be fit for arguably the biggest league game of the season due to a hamstring injury he suffered against Peterborough last month.
The Reds have a fully fit squad after Trent Alexander-Arnold and Naby Keita returned from hamstring and knee injuries respectively that were sustained before the international break.
Callum Hudson-Odoi remains out of action with an Achilles injury, while Romelu Lukaku and Hakim Ziyech are doubts ahead of the Southampton match as both were not in training after their 3-1 loss to Real Madrid.
Thomas Tuchel said Lukaku is suffering from a “painful” Achilles.
Left wing-backs Sergio Reguilon and Ryan Sessegnon returned to team training following their knee and hamstring injuries respectively, but Oliver Skipp is “not ready” to return from his pelvic injury which has kept him out of action since January.
Left-back Kieran Tierney underwent knee surgery, which puts him out for the season, after picking up the injury on international break with Scotland.
The absence of the No 3 is not the only injury for Arsenal as Thomas Partey was substituted against Crystal Palace after aggravating his thigh.
Mikel Arteta revealed the Ghanaian will be out for “some weeks” after sustaining “muscle damage”. The midfielder will “receive further specialist consultations”.
With two more key injuries, fans are impatiently waiting on Takehiro Tomiyasu who injured both calves earlier this year.
Cristiano Ronaldo is back after missing the 1-1 draw against Leicester due to illness, but three other first-team players will miss the trip to Everton.
Luke Shaw is experiencing problems relating to the broken leg he suffered in 2015 against PSV, which is why he was substituted at half-time against Leicester.
Edinson Cavani is still out with a foot problem he picked up on international duty with Uruguay, along with Raphael Varane, who picked up a knock with France despite playing in last week’s draw.
Scott McTominay is the newest addition to the injury list, also sustaining a foot injury at Old Trafford.
Kalvin Philips came on as a substitute against Southampton in a 1-1 draw after recovering from a hamstring surgery which put him out of action since the 2-2 draw with Brentford in December.
Liam Cooper also returned against Southampton, starting his first game since their November 1-0 win against Crystal Palace, when he sustained a hamstring injury.
On loan defender Ozan Kabak returned to parent club Schalke due to a “significant hamstring injury that’s ruled him out for the rest of the season,” said Dean Smith.
However Lukas Rupp with a hamstring injury and Brandon Williams are back in training today.